Human lysyl oxidase-like 2
نویسندگان
چکیده
منابع مشابه
LOXL2 (lysyl oxidase-like 2)
The LOXL2 gene is located on chromosome 8p21.2p21.3 (Jourdan-Le Saux et al., 1998). It is composed of fourteen exons and thirteen introns, distributed through approximately 107 kb of genomic DNA (Fong et al., 2007). Two transcripts of sizes 3.6 kb and 4.9 kb have been reported, with the smaller transcript much more abundant and resulting from three possible termination sites located 690 bp, 740...
متن کاملLOXL3 (lysyl oxidase-like 3)
Note LOXL3 is part of the lysyl oxidase (LOX) family, the members of which are secreted extracellular matrix enzymes. LOXL3 contains a C-terminal region that is conserved in all five isoforms of this copper-dependent amine oxidase family. The domains included within this region are a copper-binding site, lysyl and tyrosine residues that form the lysyltyrosine-quinone cofactor (LTQ) and a cytoki...
متن کاملInhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer
Lysyl oxidase (LOX) and LOX-like (LOXL) enzymes are key players in extracellular matrix deposition and maturation. LOX promote tumour progression and metastasis, but it may also have tumour-inhibitory effects. Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue. In...
متن کاملLysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Lysyl oxidase-like 2 (LOXL2) is involved in a wide range of physiological and pathological processes, including fibrosis and tumor progression, implicating intracellular and extracellular functions. To explore the specific in vivo role of LOXL2 in physiological and tumor contexts, we generated conditional gain- and loss-of-function mouse models. Germ-line deletion of Loxl2 promotes lethality in...
متن کاملLysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Lysyl oxidase-like 2 (Loxl2) interacts with and stabilizes Snai1 transcription factor, promoting epithelial-mesenchymal transition. Either Loxl2 or Snai1 knock-down blocks tumor growth and induces differentiation, but the specific role of each factor in tumor progression is still unknown. Comparison of the gene expression profiles of the squamous cell carcinoma cell line HaCa4 after knocking-do...
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ژورنال
عنوان ژورنال: Bioorganic Chemistry
سال: 2014
ISSN: 0045-2068
DOI: 10.1016/j.bioorg.2014.07.003